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International Journal of Pharma Sciences is an open access bi-monthly journal covering all aspects of latest research in pharmacy and pharmaceutical sciences.
2018
Volume 8, Issue-4 (July-August 2018)
ABSTRACT: The main study applied on the biochemical effects of probiotics on hepatic Lipid Metabolism experimentally induced Nonalcoholic fatty liver disease [NAFLD] in rats. Thirty male albino rats were divided into three groups [10 rats each]. The first group fed a normal diet and represents the control group. The second group [NAFLD] fed normal diet enriched with1% cholesterol and 2% coconut oil and act as positive control [+ ve control]. The third group fed on normal diet enriched with1% cholesterol and 2% coconut oil and probiotics [BIO-BC™] at a dose of 1-2g/liter at a rat dose[0.5-1ml/kg. body. weight]. Samples collected after 2,4and6 weeks after induction from treatment. Serum was collected for estimation of serum Tumor necrosis factor alpha [TNFα] , Interlukein-6 [IL-6] .Our results showed a significant increase in serum TNFα, IL-6. The behavioral biochemical results indicated treatment with probiotics showed significant changes and improved these parameters.
KeyWords: NAFLD, Probiotics, Pro-inflammatory cytokines.
How to cite: Omayma A.R. AboZaid et al. Ameliorative Effect of probiotics on Anti-inflammatory markers [TNFα, IL6] on hepatic Lipid Metabolism Experimentally Induced Non Alcoholic Fatty Liver Disease in Rats. Int J Pharma Sci. 8(4) 2018: 1956-1959
ABSTRACT: This study was carried out to evaluate the antitumor activity of citrus pectin (CP) and irradiated citrus pectin (Irr.CP) on 60 female mice and weighting 20-25 g. the mice were divided into four equal groups of 15 mice. Group 1: Non-tumor bearing mice (NTBM).Group 2:Tumor bearing mice (TBM). Group 3:TBM-treated with citrus pectin orally (3.3g/kg.b.w./day) for 4 weeks .Group 4:TBM-treated with Irr.CP orally (3.3g/kg.b.w./day) for 4 weeks. Blood samples were collected from all animal groups after 2 and 4 weeks from the onset of treatment and processed directly for determination of SOD, GPx, and CAT activities in addition to MDA, GSH, and NO(x) concentrations. Also, AST , ALT and GGT activities as well as urea and creatinine concentrations were also determined in blood. The obtained results revealed a significant increase in MDA , No(x) level , CAT activity and in liver and kidney functions ratios, a marked significant depletion in GSH content ,GPx and SOD activity in the blood of tumor bearing mice compared to control. Contrary results obtained in TBM treated with CP and Irr.CP. So, these compounds have potential benefits in cancer treatment.
KeyWords: irradiated citrus pectin, Tumor bearing, cancer, antioxidants.
How to cite: Omayma A.R. AboZaid et al. Biochemical Evaluation of Antitumor Activity of Irradiated Citrus Pectin: oxidants and antioxidants content. Int J Pharma Sci. 8(4) 2018: 1960-1964
ABSTRACT: Recent trends in controlling and treating diseases tend to prefer natural drugs rather than synthetic ones.Plants are considered to be the nature's Green pharmacy, which provide drugs to maintain good health of human being. The medicinal value of these plants lies in its constituents like alkaloids, cardiac glycosides, saponins, flavonoids, volatile oils, steroids and minerals. The seeds of Citrullus colocynthis were analysed for chemical, physicochemical and phytochemical properties using standard methods. The seeds contained moisture 6.96g,ash 1.98g,protien 22.31g, fiber 2.72g,lipid 52.37 g, phospholipids 12.75 g and carbohydrate 14.22 and in mg / 100 g DM, phosphorus 510.27 and calcium 52.17. The seeds were found to be slightly acidity with a pH value of 5.27. Other physical characters include specific gravity 1.0123, titratable acidity 1.79 , total soluble solids 8.81 and refractive index 1.4332. Oil of kernel 54.97± 0.91 %, oil of the unshelled seed 43.3±0.73%, moisture content 0.17 ± 0.04 %, free fatty acid content 0.67± 0.17% , iodine value 107.9± 1.8 , saponification value 210.8± 5.31, peroxide value 6.51±0.03 and unsaponifiable matter content 0.98 ± 0.07 g. The values of all the analysis are the average of six replicates. The identification of the active ingredients (glycosides, alkaloids and saponins) by using phytochemical technique such as chemical tests,colour reactions and thin layer chromatography is very important and support the chemical and physicochemical analysis. Also, the hypoglycemic and antihyperglycemic effects of an alcoholic extract of the fruit of Citrullus colocynthis was investigated in both normal and alloxan- induced diabetes in adult albino rats. Blood samples were collected before and at 0.5, 1, 2, 4, 6, and 8 h. after the oral administration of 100, 200, and 300 mg/kg. Graded dose of the extract given to both normal and diabetic rats produced significant reductions in blood glucose at 6 h. after extract administration (P< 0.001). The effect was found to be dose dependent with all treatments at the doses administered. The present study clearly indicated a significant antidiabetic activity of the fruit of Citrullus colocynthis.
KeyWords: Citrullus colocynthis, phytochemical technique, antidiabetic activity, unsaponifiable matter, antihyperglycemic.
How to cite: Medhat Fawzy Mahmod et al. Phytochemical Properties and Anti-diabetic Effects of Citrullus colocynthis extract in Alloxan induced-Diabetic Rats. Int J Pharma Sci. 8(4) 2018: 1965-1974
