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International Journal of Pharma Sciences is an open access bi-monthly journal covering all aspects of latest research in pharmacy and pharmaceutical sciences.
2017
Volume 7, Issue-4 (July-August 2017)
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...........in progress
ABSTRACT: Due to the increasing resistance to bacteria, there is urgency for development of alternative therapies on bacterial induced diseases and disorders. Herbal formulations can serve as good alternative due to their enhanced effect and lesser side effects. This study was aimed to develop herbal formulation (gel) with a new combination of Neem and Coriander leaves extract, owing to the presence of chemical constituents that can lead to the treatment of acne vulgaris in terms of their antibacterial, antioxidant and anti-inflammatory properties which provide an enhanced and targeted effect in this formulation. Herbal gel formulations were developed by using extract of neem and coriander leaf extracts. All formulations were evaluated for physical parameters like color, consistency, viscosity and extrudability. Phytochemical analysis of extract was done to determine major chemical constituents in each extract. Antibacterial activity was determined by disc diffusion method against strains of Staphylococcus epidermidis and Propionibacterium acnes both of which contributes to the development of acne and compared against standard antibiotic clindamycin. Combination of Extracts of Neem and coriander shows maximum zone of inhibitions in synergism but less as compared to Clindamycin.
KeyWords: Acne vulgaris, herbal formulation, antibacterial activity.
How to cite: Tayyaba Sadiq et al. Assessment of antibacterial activity of Neem and Coriander Leaves extract against Staphylococcus epidermidis and Propionibacterium acnes: Development and formulation of herbal anti-acne gel. Int J Pharma Sci. 7(4) 2017: 1803-1807
ABSTRACT: 5-Amino-3-methyl-1-phenyl-1H-thieno[3,2-c]pyrazole-6-carbonitrile (3a) was synthesized via Gewald reaction and used as starting materials for the synthesis of new series of, pyrazolo[3',4':4,5]thieno[2,3-b]pyridine derivatives and pyrazolo[3',4':4,5]thieno[2,3-d]-pyrimidine derivatives. Also ethyl 5-amino-3-methyl-1-phenyl-1H-thieno[3,2-c]pyrazole-6-carboxylate (3b) was used to synthesize a new series of pyrazolo[3',4':4,5]thieno[2,3-d]-pyrimidine derivative. The structure of the newly synthesized compounds was established based on elemental analysis and IR, 1H NMR, 13C NMR and MS spectra. Some of the newly synthesized compounds were screened for antibacterial and antifungal activity.
KeyWords: Gewald reaction, Thienopyrazoles, Pyrazolothienpyridines, Pyrazolothienopyrimidines, Antimicrobial Activities.
How to cite: Mohamed A. M. Gad-Elkareem et al. Synthesis and Antimicrobial Evaluation of Some New Thienopyrazoles, Pyrazolothienopyridines and Pyrazolothienopyrimidines via Gewald reaction. Int J Pharma Sci. 7(4) 2017: 1808-1816
ABSTRACT: The present study was undertaken to evaluate the possible synergistic effect of oxygenated water with doxorubicin against diethylnitrosamine-induced hepatocellular carcinoma in rats. Hepatocellular carcinoma was induced by diethylnitrosamine added to the drinking water at a dose of (100 mg/L) for 8 consecutive weeks followed by 8 weeks of drinking tap water. Diethylnitrosamine administration caused elevation in serum liver enzymes, serum tumor markers, caspase-3 content and depletion of the antioxidant enzymes in the liver tissue. This was confirmed by histopathological investigations. Interestingly, treatment with oxygenated water (5 ml/kg/day, p.o) concurrently with intravenous doxorubicin administration via tail vein (2.5 mg/kg/week) for 4 weeks starting from the 13th week corrected serum liver enzymes, caused significant decrease in serum tumor markers, increased the hepatic tissue content of caspase-3, restored the depleted antioxidant enzymes and corrected the histopathological finding. In conclusion, oxygenated water enhanced the doxorubicin efficacy, most likely due to the anti-hypoxic effect.
KeyWords: Hepatocellular Carcinoma; Diethylnitrosamine; Oxygenated water; Doxorubicin; Hypoxia.
How to cite: Mohamed AM. El-Boreay et al. Oxygenated Water could augment Doxorubicin to act against Diethylnitrosamine induced Hepatocellular Carcinoma in Rats. Int J Pharma Sci. 7(4) 2017: 1817-1825
ABSTRACT: The pharmacokinetics (after single oral, i.m. and i.v. administration) and tissue residues after repeated oral (daily for five days) and i.m. (daily for two days) administration of apramycin were investigated in healthy broiler chickens. Apramycin was administered at a dose level of 25 mg/kg b. wt. (for oral and i.m. administration) and at 10 mg/kg b. wt. for i.v. injection. Seventy clinically healthy Hubbard chickens of 1.65~2 kg b.wt. and of 45 days old, were used in the current study. The maximum plasma concentrations of apramycin were achieved 0.18 and 0.70 h after oral and i.m. administration with an absorption half-life (t1/2ab.) of 0.11 and 0.18 h and an elimination half-life (t1/2β) of 1.23 and 2.33 h, respectively. The systemic bioavailability was 2.5 and 60.5 % after oral and i.m. administration, respectively, indicating poor oral absorption of apramycin. After i.v. injection, the pharmacokinetics of apramycin was best described by a two-compartment open model with a t1/2α of 1.55 h, tl/2β of 2.15 h, Vdss of 4.85 litre/kg and Clβ of 1.9 litre/kg/h. The plasma protein binding of apramycin was 25.0 ± 2.45 %. The highest tissue concentrations of apramycin were present in kidneys and liver. No apramycin residues were detected in tissues after 6 h except in liver and kidneys following oral dosing.
KeyWords: Apramycin; Pharmacokinetics; Bioavailability; Residues; Broiler chickens.
How to cite: Mohamed Elbadawy et al. Pharmacokinetic, bioavailability and tissue residues of apramycin in broiler chickens. Int J Pharma Sci. 7(4) 2017: 1826-1831
ABSTRACT: In the present study, an attempt was made to formulate and evaluate Gastro Retentive Drug Delivery Systems of Gatifloxacin which inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Estimation of Gatifloxacin carried out spectrophotometrically at 292nm. The floating tablets of Gatifloxacin, with different polymers release a therapeutic amount of Gatifloxacin to achieve and maintain the desired concentration. Direct compression method was used for formulation of floating tablets. Different types of polymers like HPMC K100M, Sodium CMC, Chitosan and Guar gum were studied for effervescent tablets. The release rate could effectively be modified by varying the “polymer” concentration. The optimized F3 formulation a prepared with HPMC K100M (90mg conc) passed all evaluation tests and showed best results like weight variation 448.54 (mg), Hardness (kg/cm2), thickness (4.41nm), Friability (0.42%), Drug content uniformity (99.93%), Floating lag time 94 sec, Swelling Index (49%) and the % drug release is 99.53% in 12 hrs. The drug release kinetics indicates that the formulation follows zero order release and diffusion mechanism.
KeyWords: Gatifloxacin, floating tablets, HPMC K100M, Sodium CMC, Chitosan and Guar gum.
How to cite: Sindhu Sadasivuni et al. Formulation and Evaluation of GRDDS of Gatifloxacin. Int J Pharma Sci. 7(4) 2017: 1832-1838
