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International Journal of Pharma Sciences is an open access bi-monthly journal covering all aspects of latest research in pharmacy and pharmaceutical sciences.
2018
Volume 8, Issue-2 (March-April 2018)
ABSTRACT: An efficient, commercially viable and safe synthetic process for the preparation of a diagnostic drug substance, isosulfanblue sodium with a purity of more than 99.8% was demonstrated. This four stage synthetic process has several advantages over the earlier reported procedures and meeting all the regulatory requirements. The present work further describes the formation and control of the possible impurities.
KeyWords: Cancer diagnostic, 2-Chloro Benzaldehyde, N,N-Diethyl aniline, Isosulfanblue, Cheaper oxidizing agent.
How to cite: Chandra Sekhara Rao Nethinti et al. An efficient, commercially viable and safe process for preparation of Isosulfanblue sodium. Int J Pharma Sci. 8(2) 2018: 1908-1913
ABSTRACT: The proposed study is to develop Accurate, precise, simple and reliable method for the simultaneous estimation of the Darunavir and Cobicistat Tablet Dosage Form. Mobile phase with 40% OPA (0.1%): 60% Acetonitrile was run through Standard Altima C18 (4.6 x 150mm, 5µm) column at a rate of 0.8ml/min. at Temperature 30°C and Optimized wavelength was 210nm. Retention time of 2.000min and 2.497 min and %RSD of 0.1%and 0.3% and %Recovery of 99.31% and 99.59% were obtained for Darunavir and Cobicistat respectively. The Limit of Detection (LOD) and Limit of quantification (LOQ) values obtained from regression equations of Darunavir and Cobicistat were 0.04, 0.12 and 0.14, 0.42 respectively. Regression equation of Darunavir is y =32586.x+5913, and y = 40386.x + 3363 of Cobicistat. Retention times and run time were decreased and the Recovery percentage was high which indicates Accuracy of Method, so the method was precise and reliable which is also economical that can be apt to be adopted in regular Quality control test in Industries.
KeyWords: Darunavir, Cobicistat, HPLC.
How to cite: B. Pavani Venkat et al. RP-HPLC Method Development and Validation for the Simultaneous Estimation of Darunavir and Cobicistat in Bulk and Tablet Dosage Form. Int J Pharma Sci. 8(2) 2018: 1914-1923
ABSTRACT: Nicardipine supported discharge tablets were planned by utilizing distinctive excipients by wet granulation strategy. All the physicochemical tests were performed and the outcomes were in the points of confinement according to ICH rules. The detailed granules were under taken for all the post pressure tests and the outcomes were in limits according to IP. Add up to 13 definitions were readied, disintegration was performed for 12 hrs, as the % tranquilize discharge by disintegration for F7 detailing is most extreme, thus F7 plan is chosen as improved among F1 – F13.
KeyWords: Nicardipine, ICH rules, Post pressure Optimized.
How to cite: U.N.V. Sai Rohit et al. Formulation and Evaluation of Nicardipine Sustained Release Tablets. Int J Pharma Sci. 8(2) 2018: 1924-1929
ABSTRACT: Montelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma, chronic asthma attacks and to relive symptoms of seasonal allergies. The main drawback of conventional Montelukast sodium formulation is that it undergoes hepatic first pass metabolism. Thus, it shows plasma or biological half-life 2.5 to 5.5 hrs, administered as oral tablets at high doses 2-3 times per day. Thus it is decided to prolong the gastric residence time in terms of making floating gastro retentive drug delivery system to increase drug absorption and hence bioavailability. Totally 12 formulations were formulated by using the above drugs by using two different techniques like Effervescent floating technique and Non Effervescent floating technique. Among them Formulations F1-F12 were formulated by using Montelukast sodium as a drug, whereas the formulations F1-F6 were formulated by Effervescent floating technique and formulations F7-F12 were formulated by Non Effervescent floating technique. All the formulations were evaluated for the pre compression and post compression parameters and all the formulations shows acceptable limits. The in vitro drug release profiles of the formulations F1-F12 the maximum drug release was found in the F12 formulation containing polyox WSR(90mg) as a rate retarding polymer.
KeyWords: Montelukast sodium, Polyox WSR, floating gastro retentive drug delivery system.
How to cite: MD. Bala Pasha et al. Formulation and Evaluation of Gastro Retentive Floating Tablets of Montelukast Sodium. Int J Pharma Sci. 8(2) 2018: 1930-1933
